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Implant fibrosis and the underappreciated role of myofibroblasts in the foreign body reaction

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iNOS are mainly found in fibroblasts, and a large amount of NO is synthesized in skin healing and skin inflammation caused by UV irradiation (40, 41)

The latter regulates the Nrf2-ARE pathway mainly through phosphorylation sites and is considered a critical regulatory factor of Nrf2 nuclear accumulation, nuclear rejection, and degradation